张子超  教授 博士生导师

电话：025-83790939

Email：zhangzc@seu.edu.cn

个人简介

1998-2002年，南京大学，生物化学专业，学士

2002-2005年，南京大学，生物化学与分子生物学，硕士

2005-2011年，美国得克萨斯州大学西南医学中心，细胞调控专业，博士

2011-2012年，美国得克萨斯州大学西南医学中心，药理系，博士后

2012年-现在，澳门网上赌搏平台，澳门网上赌搏平台院研究院，副教授

研究方向：

儿童智力发育迟缓和老年人群中的神经退行性疾病是常见多发的神经系统疾病，目前人们对其复杂的发病机理知之甚少，缺乏有效的治疗手段，是生物医学领域里未解的难题。对神经发育，突触形成和维持，神经递质的传递和神经环路形成过程中关键分子及分子事件的研究是解开难题的核心。我们主要运用生物化学与分子生物学，细胞生物学，结构生物学，生物信息学和遗传学等方法与手段，通过对细胞内蛋白质的表达调控，蛋白质之间的相互作用，蛋白质和RNA等生物大分子在细胞内的转运以及相应细胞生理生化功能的研究，来揭示神经发育与退化过程的分子机制，探讨智力发育迟缓和神经退行性性疾病的发病机理，寻找新的治疗手段。

代表性论文：

1. Zhang ZC, Han J. The First National Prevalence of Autism Spectrum Disorder in China. Neurosci Bull. 2020 Sep;36(9):959-960. doi: 10.1007/s12264-020-00571-x. Epub 2020 Aug 29. PubMed PMID: 32860208; PubMed Central PMCID: PMC7475156.

2. Gu Q, Wu J, Tian Y, Cheng S, Zhang ZC, Han J. Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila. J Biol Chem. 2020 Apr 24;295(17):5554-5563. doi: 10.1074/jbc.RA120.012764. Epub 2020 Mar 20. PubMed PMID: 32198182; PubMed Central PMCID: PMC7186184.

3. Liu X, Dou LX, Han J, Zhang ZC. The Renpenning syndrome-associated protein PQBP1 facilitates the nuclear import of splicing factor TXNL4A through the karyopherin β2 receptor. J Biol Chem. 2020 Mar 27;295(13):4093-4100. doi: 10.1074/jbc.RA119.012214. Epub 2020 Feb 10. PubMed PMID: 32041777; PubMed Central PMCID: PMC7105315.

4. Mu Y, Tian Y, Zhang ZC, Han J. Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the  adaptor protein AP2. J Biol Chem. 2019 Jul 19. pii: jbc.RA119.009602. doi: 10.1074/jbc.RA119.009602. [Epub ahead of print] PubMed [citation] PMID: 31324721

5. Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 2018 Apr 19;173(3):677-692.e20. doi: 10.1016/j.cell.2018.03.002. PubMed [citation] PMID: 29677512, PMCID: PMC5911940

6. Li Q, Li Y, Wang X, Qi J, Jin X, Tong H, Zhou Z, Zhang ZC, Han J. Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABA(A) Receptor. Curr Biol. 2017 Dec 4;27(23):3616-3625.e5. doi: 10.1016/j.cub.2017.10.052. Epub 2017 Nov 22. PubMed [citation] PMID: 29174887

7. Tian Y, Zhang ZC, Han J. Drosophila Studies on Autism Spectrum Disorders. Neurosci Bull. 2017 Dec;33(6):737-746. doi: 10.1007/s12264-017-0166-6. Epub 2017   Aug 9. Review. PubMed [citation] PMID: 28795356, PMCID: PMC5725381

8. Zhang XY, Qi J, Shen YQ, Liu X, Liu A, Zhou Z, Han J, Zhang ZC. Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction. Hum Mol Genet. 2017 Mar 1;26(5):955-968. doi: 10.1093/hmg/ddx010. PubMed [citation] PMID: 28073926

9. Tong H, Li Q, Zhang ZC, Li Y, Han J. Neurexin regulates nighttime sleep by modulating synaptic transmission. Sci Rep. 2016 Dec 1;6:38246. doi: 10.1038/srep38246. PubMed [citation] PMID: 27905548, PMCID: PMC5131284

10. Wei JH, Zhang ZC, Wynn RM, Seemann J. GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules. Cell. 2015 Jul 16;162(2):287-299. doi: 10.1016/j.cell.2015.06.014. Epub 2015 Jul 9. PubMed [citation] PMID: 26165940, PMCID: PMC4506739

11. Wan D, Zhang ZC, Zhang X, Li Q, Han J. X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs. Hum Mol Genet. 2015 Aug 15;24(16):4599-614. doi: 10.1093/hmg/ddv191. Epub 2015 May 22. PubMed [citation] PMID: 26002102

12. Li Y, Zhou Z, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W, Han J. Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. J Neurosci. 2013 Sep 25;33(39):15545-54. doi: 10.1523/JNEUROSCI.0819-13.2013. PubMed [citation] PMID: 24068821, PMCID: PMC6618453

13. Tian Y, Li T, Sun M, Wan D, Li Q, Li P, Zhang ZC, Han J, Xie W. Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation. Neuron. 2013 Jan 23;77(2):311-22. doi: 10.1016/j.neuron.2012.11.012.   PubMed [citation] PMID: 23352167

14. Etchin J, Sun Q, Kentsis A, Farmer A, Zhang ZC, Sanda T, Mansour MR, Barcelo C, McCauley D, Kauffman M, Shacham S, Christie AL, Kung AL, Rodig SJ, Chook YM, Look AT. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia. 2013 Jan;27(1):66-74. doi: 10.1038/leu.2012.219. Epub 2012 Jul 31. PubMed [citation] PMID: 22847027, PMCID: PMC3542631

15. Zhang ZC, Chook YM. Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS). Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12017-21. doi: 10.1073/pnas.1207247109. Epub 2012 Jul 9. PubMed [citation] PMID: 22778397, PMCID: PMC3409756

16. Zhang ZC, Satterly N, Fontoura BM, Chook YM. Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1. Mol BiolCell. 2011 Dec;22(23):4657-68. doi: 10.1091/mbc.E11-03-0222. Epub 2011 Sep 30. PubMed [citation] PMID: 21965294, PMCID: PMC3226482

17. Qian F, Li YP, Sheng X, Zhang ZC, Song R, Dong W, Cao SX, Hua ZC, Xu Q. PRL-3 siRNA inhibits the metastasis of B16-BL6 mouse melanoma cells in vitro and in vivo. Mol Med. 2007 Mar-Apr;13(3-4):151-9. Erratum in: Mol Med. 2007 May-Jun;13(5-6):325. PubMed [citation] PMID: 17592549, PMCID: PMC1892759

18. Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM. Structure-based design of a pathway-specific nuclear import inhibitor. Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PubMed [citation] PMID: 17435768, PMCID: PMC3437620

19. Lee BJ, Cansizoglu AE, Süel KE, Louis TH, Zhang ZC, Chook YM. Rules for nuclear localization sequence recognition by karyopherin beta 2. Cell. 2006 Aug 11;126(3):543-58. PubMed [citation] PMID: 16901787, PMCID: PMC3442361

20. Qian F, Zhang ZC, Wu XF, Li YP, Xu Q. Interaction between integrin alpha(5) and fibronectin is required for metastasis of B16F10 melanoma cells. Biochem Biophys Res Commun. 2005 Aug 12;333(4):1269-75. PubMed [citation] PMID: 15979576