罗玉璇 教授，博士生导师
E-mail: yuxuanluo@seu.edu.cn
办公地点：南京市四牌楼2号，李文正南楼213室
教育和工作简历
2005年至2009年，四川大学，生物学基地班，学士
2009年至2014年，北京协和医学院，生物化学与分子生物学，博士
2014年至2017年，重庆医科大学附属第二医院
2017年至2021年，美国德克萨斯大学西南医学中心，博士后
2022年至今，澳门网上赌搏平台，澳门网上赌搏平台与技术学院，教授
研究方向：心血管疾病发病机制
心血管疾病是人类健康的“第一杀手”，每年夺走约1790万人的生命。目前人们对于心血管疾病的发病机制尚不完全清楚。本实验室聚焦心肌肥厚和心肌损伤，围绕信号通路、转录因子和线粒体，以小鼠为模式动物，运用生物化学与分子生物学、细胞生物学、表观遗传学等方法研究心血管疾病相关分子的作用机理。
近期代表性论文： （* 通讯作者; # 第一作者）
1. Yuxuan Luo, Nan Jiang, Herman I. May, Xiang Luo, Anwarul Ferdous, Gabriele G. Schiattarella, Guihao Chen, Qinfeng Li, Chao Li, Beverly A. Rothermel, Dingsheng Jiang, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. Cooperative binding of ETS2 and NFAT link Erk1/2 and calcineurin signaling in the pathogenesis of cardiac hypertrophy. Circulation. 2021;144:34-51.
2. Anwarul Ferdous, Sarvjeet Singh, Yuxuan Luo, Md. J. Abedin, Nan Jiang, Cameron E. Perry, Bret M. Evers, Thomas G. Gillette, Michael Kyba, Maria Trojanowska, Joseph A. Hill. Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors. Circulation Research. 2021;129:949–964.
3. Gabriele G. Schiattarella, Francisco Altamirano, Soo Young Kim, Dan Tong, Anwarul Ferdous, Hande Piristine , Subhajit Dasgupta, Xuliang Wang, Kristin M. French, Elisa Villalobos, Stephen B. Spurgin, Maayan Waldman, Nan Jiang, Herman I. May, Theodore M. Hill, Yuxuan Luo, Heesoo Yoo, Vlad G. Zaha, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction. Nature Communications, 2021; 12:1684.
4. Anwarul Ferdous, Zhao V. Wang, Yuxuan Luo, Dan L. Li, Xiang Luo, Gabriele G. Schiattarella, Francisco Altamirano, Herman I. May, Pavan K. Battiprolu, Annie Nguyen, Beverly A. Rothermel,Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth. Nature Communications, 2020;11:2551.
5. Yu-Xuan Luo#, Xiaoqiang Tang#, Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long Hao, Hou-Zao Chen, De-Pei Liu. Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. Eur Heart J, 2017. 38(18): p. 1389-1398.
6. Xi Jiang#, Ke-Qiong Deng#Yu-Xuan Luo#, Ding-Sheng Jiang, Lu Gao, Xiao-Fei Zhang, Peng Zhang, Guang-Nian Zhao, Xueyong Zhu, Hongliang Li. Tumor Necrosis Factor Receptor–Associated Factor 3 Is a Positive Regulator of Pathological Cardiac Hypertrophy. Hypertension, 2015. 66(2): p. 356-67.
7. Rui-Feng Yang, Li-Hong Sun, Ran Zhang, Yuan Zhang, Yu-Xuan Luo, Wei Zheng, Zhu-Qin Zhang, Hou-Zao Chen, De-Pei Liu. Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation. Sci Rep, 2015. 5: p. 7990.
8. Yuan Zhang, Jing Xu, Yu-Xuan Luo, Xi-Zhou An, Ran Zhang, Guang Liu, Hongliang Li, Hou-Zao Chen, De-Pei Liu. Overexpression of Mitofilin in the Mouse Heart Promotes Cardiac Hypertrophy in Response to Hypertrophic Stimuli. Antioxid Redox Signal, 2014. 21(12): p. 1693-707.
9. Ding-Sheng Jiang#, Yu-Xuan Luo#, Ran Zhang#, Xiao-Dong Zhang, Hou-Zao Chen, Yan Zhang, Ke Chen, Shu-Min Zhang, Guo-Chang Fan, Peter P. Liu, De-Pei Liu, Hongliang Li. Interferon Regulatory Factor 9 Protects Against Cardiac Hypertrophy by Targeting Myocardin. Hypertension, 2014. 63(1): p. 119-27.
